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March 10, 1934

Current Comment

JAMA. 1934;102(10):772-773. doi:10.1001/jama.1934.02750100038016

THE ETIOLOGY OF AGRANULOCYTOSIS  Agranulocytosis is a clinical syndrome that has been frequently reported only within the last few years. Several theories have been suggested as the cause of this highly fatal disease, but a satisfactory explanation has not yet been offered. It is important to consider carefully all the evidence presented. Madison and Squier 1 in this issue of The Journal report fourteen cases of agranulocytosis in which a definite history was obtained in each case of the use of amidopyrine (in combination with a barbital preparation, amidopyrine alone, or in one case in combination with other drugs) immediately prior to the clinical discovery of the disease. In treating these cases of agranulocytosis, the Milwaukee investigators endeavored to stimulate granulopoiesis in all of them by means of transfusions, neucleotide or yellow bone marrow extract. In eight cases the further use of amidopyrine was strictly prohibited. In the other six

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