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Article
May 3, 1941

SUCCESSFUL SUBLINGUAL THERAPY IN ADDISON'S DISEASE: A CONFIRMATIVE REPORT

Author Affiliations

Philadelphia
From the Philadelphia Institute for Medical Research and the Philadelphia General Hospital.

JAMA. 1941;116(18):2016. doi:10.1001/jama.1941.62820180004006c
Abstract

The recent report of Haymaker and his associates concerning the successful sublingual treatment of Addison's disease with desoxycorticosterone acetate in propylene glycol finds confirmation in our experience in 2 advanced cases of this disease. The patients were given 1 mg. (6 drops) under the tongue six to seven times daily; this preparation was retained for fifteen minutes and then expectorated. Salt was utilized also in the early part of the study but because of edema was discontinued. The good effects observed, we believe therefore, were due entirely to desoxycorticosterone acetate.

REPORT OF CASES1 

Case 1.—  A. S., a white woman aged 43, ailing since 1935, admitted to the Philadelphia General Hospital on Sept. 20, 1940 complained of anorexia, weakness and a loss of 45 pounds (20.4 Kg.). The pigmentation of the skin and buccal mucous membrane was characteristic. Her blood pressure was 94 systolic and 72 diastolic. A test

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