In 1922 a study was published by Moore1 which showed, after careful analysis, that pregnancy tended to protect women from the late accidents of neurosyphilis and that the apparent predominance of late neurosyphilis in men as compared to women could largely be explained on this basis. A study along the same lines appeared in 1926 by Solomon,2 who, after analyzing 559 cases, concluded that his results tended to corroborate those of Moore in ascribing to pregnancy a protective influence against late neurosyphilitic accidents.
Experimental evidence bearing on this question is found in the work of Brown and Pearce3 on the inoculation of pregnant and lactating rabbits with syphilis. These observers found that only half of the gravid and lactating animals inoculated developed evidence of primary lesions, while all the controls developed such lesions in the usual time. It is important to note, however, that in this experiment
BELOTE GH. PREGNANCY AND NEUROSYPHILIS. JAMA. 1927;89(4):268–270. doi:10.1001/jama.1927.02690040008003
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