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July 23, 1927


Author Affiliations


JAMA. 1927;89(4):273-275. doi:10.1001/jama.1927.02690040013005

During the earlier days of our experience with the guinea-pig test for diphtheria immunity, we were Schick testing and immunizing with toxin-antitoxin many children in various schools and institutional groups. Many comparative tests were made, some of the earlier ones having been previously reported.1 Primary tests by the two methods were found to agree, except for discrepancies explainable by the influence of protein reactions in obscuring the correct reading of the Schick test. Later, through the accidental inclusion of some children who were Schick negative following toxin-antitoxin immunization, in a group having blood specimens taken, it was noted that some of these gave negative Schick tests and positive Kellogg tests. The latter test is gaged to detect antitoxin in the blood in quantities of one-thirtieth unit per cubic centimeter or more, the amount generally accepted, following the work of Schick, as protective. It is performed by adding to 0.1