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Article
July 23, 1927

IMMUNITY IN TUBERCULOSIS: VACCINATION WITH LIVING VIRULENT, AVIRULENT AND DEAD TUBERCLE BACILLI

Author Affiliations

Director of Research and Clinical Laboratory, Trudeau Foundation TRUDEAU, N. Y.

JAMA. 1927;89(4):285-293. doi:10.1001/jama.1927.92690040025010
Abstract

The present general trend in the prevention of tuberculosis, apart from the sociological campaign measures, is still the search for a method of producing specific immunity which can be safely applied for practical use in children.

In dealing with such a shopworn subject as immunity in tuberculosis, a subject which has led to many controversies and a general disagreement, one must be very cautious in forming any opinion. The prevailing skepticism and apathy toward a new investigation covering some old problem is justifiable for the reason that many claims in the past when subjected to a rigid test failed to meet all the requirements.

No attempt will be made to review in detail the literature, which is voluminous and in part very contradictory, as it will be a hopeless task and will add little toward forming an hypothesis which can be used as a basis for discussion.

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