The well established demonstration of a lowered calcium content of the blood plasma as a consequence of parathyroid deficiency naturally led to the assumption of a functional relationship between calcium metabolism and the parathyroids. This is by no means the only sort of activity that has been assigned to these glandular structures; but as the estimation of calcium in the circulating fluid is a procedure that can be carried out with accuracy and affords something definite for consideration, this aspect of the subject has received more critical study. Several investigators have advanced knowledge through the added demonstration that suitable extracts of the parathyroids, introduced into the body, actually have a measurable effect on the concentration of the plasma calcium. This has afforded a concrete basis for the investigation of the parathyroid hormone. Collip has shown that the concentrated product of the acid hydrolysis of parathyroid glands, injected into animals in
THE PATHOLOGY OF OVERDOSAGE WITH PARATHYROID HORMONE. JAMA. 1927;89(4):294–295. doi:10.1001/jama.1927.02690040034011
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