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July 23, 1927

Les stupéfiants.

JAMA. 1927;89(4):314. doi:10.1001/jama.1927.02690040054036

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The author prefers the title "stupefying agents" to "narcotics" because he denies that opium and cocaine, the chief members of the group, cause sleep when they are used properly. He denies the value of animal experimentation in this field, preferring to administer the substances under investigation to himself or others, and to deduce their action by the effects that he observes. No amount of experimentation on animals affords an adequate explanation of the actions of narcotics on man because of the greater development of man's brain, and clinical studies are essential; but the method adopted by Porak can lead only to confusion for reasons that are well known. He states that he used dogs in certain experimental studies, but the protocols which he gives afford little information. This is not an indictment of animal experimentation, but the experiments described were poorly planned, or else they do not represent the complete

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