On March 26, 1941 the headquarters office of the American Medical Association received a report calling attention to the contamination with phenobarbital of certain lots of sulfathiazole, manufactured by the Winthrop Chemical Company. Immediately, steps were taken to ascertain the seriousness of the situation. As soon as definite evidence was available, on March 28, a general warning was issued to the press and over the radio by the American Medical Association. This was the first public warning against this hazard. Conforming to the policy of The Journal and of the Council on Pharmacy and Chemistry to supply information to the medical profession, The Journal published additional statements1 to warn of the potential dangers associated with the use of the contaminated material.
Available evidence indicates that the first report suggesting unusual reactions following the use of sulfathiazole - Winthrop originated in Louisville, Ky., late in December 1940. Although the manufacturers began
Fishbein M. SULFATHIAZOLE-WINTHROP CONTAMINATED WITH PHENOBARBITAL: I. INTRODUCTION. JAMA. 1941;116(20):2259. doi:10.1001/jama.1941.62820200003008
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