In two recent publications1 the results of studies on the mechanism of bromide intoxication, or so-called bromism, were set forth. In these studies the following points were established with their experimental evidence:
Ingested bromide was with difficulty passed through the renal epithelium.
Salts of bromine tend in consequence to be stored up in the tissues of the body.
Bromide displaces the chloride ion in the body, the ingestion of the former leading to rapid elimination of the latter, with consequent chloride deficiency.
In cases of bromide intoxication, the intravenous injection of physiologic sodium chloride solution leads to the liberation of the bromide from the tissues, occasionally accompanied by a sharp renal irritation.
The replacement of bromide in the tissue by chloride immediately favorably influences the symptoms of bromism, notably those in the nervous system and in the skin, causing their rapid involution.
During the past two years eight more
WILE UJ. BROMIDE INTOXICATION: FURTHER STUDIES. JAMA. 1927;89(5):340–341. doi:10.1001/jama.1927.02690050006003
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