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Article
May 24, 1941

CHEMOTHERAPY VERSUS COMBINED CHEMOTHERAPY AND SERUM: IN THE TREATMENT OF PNEUMONIA A STUDY OF 607 ALTERNATED CASES

Author Affiliations

NEW YORK
From the First (Columbia), Second (Cornell) and Fourth Medical Divisions, Bellevue Hospital, and the Departments of Medicine of the Columbia University College of Physicians and Surgeons and Cornell University Medical College, and a Committee for Pneumonia Investigation consisting of Drs. Russell L. Cecil, I. Ogden Woodruff, Asa L. Lincoln and Charles H. Nammack (the latter three, directors of the First, Second and Fourth Medical Divisions respectively) and the authors.

JAMA. 1941;116(21):2366-2371. doi:10.1001/jama.1941.02820210012002
Abstract

The universal acceptance of the value of sulfonamide therapy in pneumonia has left the role of serum as the major current problem in the treatment of this disease. Will the use of serum combined with drug reduce still further the fatality rate? Will it cause a more rapid subsidence of the acute infectious process? These problems have been studied at Bellevue Hospital by using the alternate case method. Since February 1939, all pneumonia patients entering the wards of the First, Second and Fourth medical divisions have been alternated within the pneumococcus types between sulfonamide therapy alone and combined drug and serum therapy. In the present study we are reporting the results up to Jan. 1, 1941 in a series comprising 607 patients thus alternated.

METHOD  As soon as the clinical diagnosis of pneumonia was made, samples of blood and sputum were collected for bacteriologic study. The patient was then immediately

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