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July 30, 1927


JAMA. 1927;89(5):392. doi:10.1001/jama.1927.02690050058033

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To the Editor:  —In an editorial (The Journal, July 2) in which the work of Chambers and his co-workers (Chambers, R., and Pollack, H.: J. Gen. Physiol. 10:739, 1927) was discussed and most deservedly praised, it was emphasized that the intracellular hydrogen ion concentration of living cells is remarkably unchanging and uniform except when the cells are injured. Such emphasis may be misleading to those uninformed of previous work in this field of investigation, for it has been clearly demonstrated that such fixity of reaction is not the case, particularly in functionally active secreting cells.In 1924, observations were published (Stieglitz, E. J.: Arch. Int. Med. 33:483 [April] 1924) clearly describing wide variations in intracellular hydrogen ion concentrations in the secreting renal parenchyma, and it was shown that these variations have distinct physiologic associations. Long previous to this work, Harvey and Bensley (Biol. Bull. 23:255, 1912) and

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