This is a report of a five year study comparing the therapeutic efficiency of artificial fever therapy and of therapeutic malaria. The preliminary report of this study was made in 1936.1 There is nothing unique in the use of either malarial therapy or artificial fever, the former having been advocated by Wagner von Jauregg's original report in 1917 and the latter by Neymann and Osborne2 in 1929. For reasons not entirely clear to us certain clinics treating patients with neurosyphilis have been skeptical of the therapeutic value of artificial fever in this neuropsychiatric disorder. Because of this apparent prejudice against a new method we felt it wise to observe a series of patients, taking alternate patients in the series for treatment with each method. Patients were assigned to the artificial fever or malaria series in alternation as they were admitted to the Colorado Psychopathic Hospital and Clinic, that
EWALT JR, EBAUGH FG. TREATMENT OF DEMENTIA PARALYTICA: A FIVE YEAR COMPARATIVE STUDY OF ARTIFICIAL FEVER THERAPY AND THERAPEUTIC MALARIA IN TWO HUNDRED AND THIRTY-TWO CASES. JAMA. 1941;116(22):2474–2477. doi:10.1001/jama.1941.02820220016003
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