As in other domains of science, there are problems in physiology that are subjected to frequent shifts in their solution. The long continued debate of the myogenic versus the neurogenic origin of the heart beat affords a familiar example of conclusions changing with pendulum-like swing as each new item of evidence is discovered. A somewhat similar uncertainty seems to attend the explanation of the regulation of the flow of bile and the rôle of the gallbladder. Thus in contradiction to the earlier theory that the resistance to a continuous flow of bile into the intestine is afforded by the activity of a distinct sphincter at the mouth of the common bile duct has arisen the view that the stasis referred to is really due to the tonicity of the adjacent duodenum.
Closely related to the function just discussed is the problem of the filling and emptying of the gallbladder. Whether
REGULATION OF THE BILE FLOW. JAMA. 1927;89(6):452–453. doi:10.1001/jama.1927.02690060032014