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August 13, 1927


Author Affiliations

Athens, Greece

JAMA. 1927;89(7):523. doi:10.1001/jama.1927.92690070001012a

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Dr. Vincent, twenty years ago, pointed out that bile has an anatoxic effect on the germs of the intestinal flora, and by some recent experiments he proved that there were some albumins on which bile had a special effect, and called them the cryptotoxins. Ramon, Berthelot, Grasset and Miss Amoureux have studied the effect of bile on different toxins and fungi (tetanus, colon bacillus, dysentery and anthrax). It is understood that bile composed of lipoids, soap, fat and pigments has a colloid substance. It would be more interesting to study the effect of bile on germs for which it is a favorable culture medium: I mean the typhosus and paratyphosus groups.

For that purpose I performed the following experiments: 1. Five cubic centimeters of a broth culture of B. typhosus injected into the peritoneal cavity of a rabbit weighing 750 Gm. killed the animal in twelve

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