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August 13, 1927


JAMA. 1927;89(7):525. doi:10.1001/jama.1927.02690070035015

A recent writer,1 himself a competent investigator in the field of tuberculosis, has justified the prevailing skepticism and apathy toward new studies on the problems of immunity in this disease for the reason that many claims in the past, when subjected to a rigid test, failed to meet all the requirements. Despite this attitude there has by no means been an entire lack of interest in the possibilities of prophylactic immunization. The evidence for a widespread occurrence of infection with an apparently low death rate gives strong substantiation of the development of a natural resistance to tuberculosis; this in turn justifies the hope of securing added protection through the artificial stimulation of the protective mechanism.

The procedures for attempting this have involved for the most part the use of tubercle bacilli in one form or another. Theoretically, artificial immunization with living virulent micro-organisms is a logical method. It has,