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June 14, 1941


JAMA. 1941;116(24):2679-2683. doi:10.1001/jama.1941.62820240012010a

The advances made in adrenal and sex endocrinology during the past decade have materially broadened and to some extent rationalized our conceptions about the essential nature of the adrenogenital syndrome. In keeping with the general intent of this series, the endocrinologic and biochemical aspects have been preferentially treated in this article, at the expense of the clinical and pathologic features. A brief description of the latter aspects will suffice as a background for the topics more specifically discussed here.1

The adrenogenital syndrome in the broadest sense of the term comprises all conditions in which the abnormal changes in the sexual sphere are referable to organic or functional disturbances in the adrenal cortex. It is far more frequently seen in females, in whom the changes consist in the appearance of the male secondary sex characteristics and the repression of female characters and function: adrenal virilism. In general, the earlier in