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Article
June 21, 1941

THE SYMPATHOMIMETIC AMINES AS EPINEPHRINE SUBSTITUTESA GENERAL SUMMARY

JAMA. 1941;116(25):2769-2771. doi:10.1001/jama.1941.62820250018008
Abstract

Since the introduction of epinephrine as a therapeutic agent some forty years ago, there has been an increasing interest in possible synthetic substitutes which might have advantageous qualities over that of the original drug. Ephedrine and tyramine, which occur in nature, have been thoroughly studied but are being encroached on by synthetic agents of related structure. This report is concerned with certain aspects of the chemical composition and actions of those members of this group which are now being advocated and made available in this country for clinical use.

GENERAL CIRCULATION  The most striking action of these drugs is their power to stimulate the circulation. The pressor effects are produced by arteriolar constriction and possibly increased cardiac output accompanied by variable effects on heart rate. The pulse rate effects are variable since, although the drugs tend to cause great acceleration, this may be changed to distinct slowing if the vagus

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