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June 28, 1941


JAMA. 1941;116(26):2855. doi:10.1001/jama.1941.02820260029009

The recent increased interest in the importance of plasma in the treatment of surgical shock has focused attention again on the question of the origin of the proteins in the plasma. Unlike tissue proteins, which are manufactured by each cell for its own purposes, the plasma proteins must be synthesized and excreted into the circulating blood, perhaps in the same manner as are hormones. Many physiologists believe that the liver is the main if not the sole manufactory for one or more of the plasma proteins. Certainly the albumin fraction of the plasma is frequently low in serious hepatic disease. In a brief but provocative discussion entitled "The Liver Proteins," J. Murray Luck1 asserts that fibrinogen, an important protein fraction of plasma, undoubtedly originates in the liver. The evidence of the origin of albumin and globulin is conflicting in spite of many experimental and clinical studies. Luck, in his