The current widespread interest in the therapeutic and prophylactic use of the fat-soluble vitamins, notably as they are available in cod liver oil and concentrates prepared from it, makes timely every reference to their possible limitations or alterations in efficacy. We have already referred to the suggestion of Hart, Steenbock and others1 that the concentrate of vitamins A and D represented by the nonsaponifiable fraction of cod liver oil is not effective in herbivora unless it is fed dissolved in oil. More recent studies of Daniels and Brooks2 at the Child Welfare Research Station of the University of Iowa confirm these observations in the case of an omnivorous species. The outcome makes one question the advisability of attempting to supply the vitamins to man in the form of dry concentrates unless the latter are given in oil or in close proximity to a meal that carries fats.
SOME RECENT OBSERVATIONS ON FAT-SOLUBLE VITAMINS. JAMA. 1927;89(9):694. doi:10.1001/jama.1927.02690090044014
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