Since the report in 1929 by Howland and his associates1 of a case of dysinsulinism due to an adenoma of the pancreas in which operation was successful, the number of cases reported has increased rapidly. In a recent article Frantz2 listed 96 cases of tumors of the islet cells found at operation or at autopsy.
It is difficult to determine the exact number of tumors of the islet cells reported to date, since the same cases are cited two and three times by various authors. From a careful investigation of the literature we have gathered 71 cases (table 1) of tumors of the islets of Langerhans in which the diagnosis was made preoperatively and confirmed at operation. These include 5 cases of carcinoma of the islands of Langerhans with gross metastases.
Of the 71 patients 53 were completely relieved of symptoms postoperatively, 12 died at operation or shortly
MEYER KA, AMTMAN L, PERLMAN L. ISLET CELL TUMORS OF THE PANCREAS: REPORT OF CASE. JAMA. 1941;117(1):16–20. doi:10.1001/jama.1941.02820270016006
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