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Article
July 12, 1941

THE RENAL BLOOD FLOW IN HYPERTENSION: AS DETERMINED IN PATIENTS WITH VARIABLE, WITH EARLY AND WITH LONG-STANDING HYPERTENSION

Author Affiliations

SAN FRANCISCO
From the Harold Brunn Institute for Cardio-Vascular Research, Mount Zion Hospital.

JAMA. 1941;117(2):92-95. doi:10.1001/jama.1941.02820280014004
Abstract

Experimental hypertension by the production of renal ischemia1 suggests the possibility that the same abnormality underlies the mechanism of human hypertension. Smith and his associates2 examined patients with essential hypertension by means of the diodrast clearance test3 and reported a reduction in the renal blood flow. However, Chesley and his associates,4 employing the same method of determining the renal blood flow, reported that the hypertension found in women suffering from toxemia of pregnancy was not associated with a reduction in renal blood flow, and they were not able to detect a diminution in renal blood flow in all cases of essential hypertension. Thus there are as yet a relative paucity of information and a lack of complete uniformity in the reports available concerning the relationship of renal blood flow to clinical hypertension. It appeared possible to elucidate this relationship further by means of a study which

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