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Lab Reports
March 1, 2016

Scientists Generate 3D Images of Cardiac Cell Connectors

Author Affiliations

Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2016;315(9):860. doi:10.1001/jama.2016.1488

Through experiments conducted in mice using nanoscale visualization techniques, researchers from the New York University School of Medicine and their colleagues have generated 3D images of cardiac intercalated discs (Leo-Macias A et al. Nat Commun. 2016;7:10342). These discs contain protein clusters that relay electrical signals and mechanical forces between heart cells to allow the heart to beat normally. Imaging, combined with mathematical simulations, revealed that intercellular adhesion and electrical excitability interrelated properties in cardiac muscle.