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Article
July 19, 1941

RECURRENT SCARRING PAINFUL APHTHAE: AMELIORATION WITH SULFATHIAZOLE IN TWO CASES

Author Affiliations

Kansas City, Mo.

JAMA. 1941;117(3):175-176. doi:10.1001/jama.1941.72820290003005a
Abstract

A rare but typical form of recurrent, scarring, painful aphthae is recognized under many names, one of which is periadenitis mucosa necrotica recurrens.1 Cases of such aphthae are all alike and like nothing else, but their cause, which I think must be a specific one, is entirely unknown. Three cases were reported by Sibley2 in 1899 as of "neurotic" origin, and Sibley cited Jacobi as having described 3 cases in 1894. These are the earliest reports I have found.

Commencing as a small nodule within and beneath the mucous membrane of the lip, cheek or tongue, a lesion increases in size, sloughs and causes severe pain, becomes a crateriform ulcer with inflamed, firm borders, runs a course uninfluenced by local treatment and eventually heals, leaving a soft, pliable, depressed, whitish scar. Several lesions may be present simultaneously. The patient, suffering over a period sometimes of many years, can

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