As in other physical states, the goal of therapy in gonadal dysfunction is to reproduce a normal condition in an abnormal body. This requires quantitative knowledge of the normal concentration of the hormones concerned in the body tissues and fluids and quantitative knowledge of their concentration in the agents used for replacement. In both cases the development of suitable assay procedures is essential.
The problem is not simple. Biologic methods, with all their attendant difficulties, must still be used in assaying many of these principles. Metabolic processes may alter certain of the substances both chemically and biologically. Because the actions of the substances are multiple, a confusingly large number of methods, based on different responses, with correspondingly many units, have been proposed. The space available permits discussion of only a few of the problems, and the same limitation prevents reference to much of the enormous amount of work done.
GUSTAVSON RG, D'AMOUR FE. GLANDULAR PHYSIOLOGY AND THERAPY: THE ASSAY OF GONADOTROPINS AND OF GONADAL HORMONES. JAMA. 1941;117(3):188–193. doi:10.1001/jama.1941.72820290016007
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