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July 19, 1941


JAMA. 1941;117(3):197. doi:10.1001/jama.1941.02820290039011

Information on the varying amounts of essential dietary factors in foodstuffs is of increasing practical value. For this reason a recent report by Bacharach1 on the distribution of nicotinic acid in foods is significant. Nicotinic acid or its amide is apparently a dietary essential for man, as it is for the dog, the pig and certain micro-organisms. The importance of nicotinic acid as an etiologic factor in pellagra seems established, although it is true that pellagrins often suffer from a multiple vitamin deficiency. Unfortunately, none of the small standardized laboratory animals are yet available for the biologic assay of nicotinic acid in foods; most of the analytic data available have been obtained with the help of chemical procedures. A number of biologic assays have been conducted with dogs as test animals, however. As pointed out by Bacharach, the degree of agreement between the biologic and some of the chemical

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