Information on the varying amounts of essential dietary factors in foodstuffs is of increasing practical value. For this reason a recent report by Bacharach1 on the distribution of nicotinic acid in foods is significant. Nicotinic acid or its amide is apparently a dietary essential for man, as it is for the dog, the pig and certain micro-organisms. The importance of nicotinic acid as an etiologic factor in pellagra seems established, although it is true that pellagrins often suffer from a multiple vitamin deficiency. Unfortunately, none of the small standardized laboratory animals are yet available for the biologic assay of nicotinic acid in foods; most of the analytic data available have been obtained with the help of chemical procedures. A number of biologic assays have been conducted with dogs as test animals, however. As pointed out by Bacharach, the degree of agreement between the biologic and some of the chemical
DISTRIBUTION OF NICOTINIC ACID IN FOODS. JAMA. 1941;117(3):197. doi:10.1001/jama.1941.02820290039011
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