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Time-to-event analysis, also called survival analysis, was used in the study by Nissen et al1 published in this issue of JAMA to compare the risk of major adverse cardiovascular events (MACE) in a noninferiority trial of a combination of naltrexone and bupropion vs placebo for overweight or obese patients with cardiovascular risk factors. The authors used a type of time-to-event analysis called Cox proportional hazards modeling to compare the risk of MACE in the 2 groups, concluding that the use of naltrexone-bupropion increased the risk of MACE per unit time by no more than a factor of 2.
Tolles J, Lewis RJ. Time-to-Event Analysis. JAMA. 2016;315(10):1046–1047. doi:10.1001/jama.2016.1825
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