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Postthrombotic syndrome is a spectrum of clinical signs and symptoms occurring in the setting of previous DVT. Manifestations range from lower extremity edema and hyperpigmentation in mild cases to lipodermatosclerosis (acute or chronic fibrosis of the skin with erythema or hyperpigmentation), atrophie blanche (avascular white fibrotic plaques), and venous ulcers in the most severe cases. Symptoms vary but typically include lower extremity pain, heaviness, and itching. The syndrome is estimated to occur in 20% to 50% of patients with DVT and is associated with lower health-related quality of life scores than arthritis, chronic lung disease, and diabetes.1
Jain A, Cifu AS. Prevention, Diagnosis, and Treatment of Postthrombotic Syndrome. JAMA. 2016;315(10):1048–1049. doi:10.1001/jama.2016.0225
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