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September 10, 1927


Author Affiliations

From the Department of Applied Immunology, Jefferson Hospital.

JAMA. 1927;89(11):863-866. doi:10.1001/jama.1927.02690110027009

A cutaneous reaction in a hypersensitive individual was first discovered by Blackley in 1873. This important discovery, neglected by the profession for the next forty years, was revived about fifteen years ago and placed on a firm clinical basis by Cooke, Walker and others. It is based on the fact that those substances which, when inhaled or taken into the body by some other means, are capable of producing asthma will also produce an urticarial wheal when brought into contact with the lower layers of the epidermis.

This report covers such tests performed in the Asthma Clinic of the Jefferson Hospital and in private practice for the last six years. All asthma patients coming to the clinic are tested as a matter of routine with about twenty-four different substances. Some new ones were added and some old ones, whose importance was not great, have been dropped from time to time.

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