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The monograph reports a study whose aim was to trace in animal experiment the clinical course of the B complex avitaminosis from its earliest manifestations to its final stage. The first part of the monograph consists of a comprehensive historical review of the discovery of vitamins, a discussion of the present status of the chemistry of vitamin B, its synthesis, physical and chemical properties, the interrelationship of vitamins, hormones and ferments, and the present status of the question of symptom complex of avitaminoses. The author studied the clinical picture of B avitaminosis in 9 dogs and 60 pigeons. Simultaneous control chronic starvation experiments were carried out on 3 dogs and 10 pigeons. After careful observations for a period of two months, the 9 normal young dogs were placed on a diet from which all thermolabile and some of the thermostable components of vitamin B complex were carefully excluded. This was
Klinika eksperimentalnogo B-avitaminoza. JAMA. 1941;117(3):233. doi:10.1001/jama.1941.02820290075032
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