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July 19, 1941

Znachenie golovnogo mozga v kholesterinovom obmene (k voprosu o roli neyroglii v patogeneze kholesterinemiy)

JAMA. 1941;117(3):234. doi:10.1001/jama.1941.02820290076038

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Gorizontov produced aseptic meningoencephalitis in dogs by subdural injection into the brain of either turpentine or silver nitrate. The comparative study of the blood cholesterol of the afferent arteries of the brain and of the blood cholesterol level of the efferent vessels of the brain demonstrated the development of hypercholesteremia in the experimental animals. This could not be explained on the basis of mobilization of cholesterol from the lipid depots of the brain; the author interprets it as the result of the increase of cholesterol synthesis in the brain. He correlated the various biochemical data obtained in his experiments with the morphologic alterations in the brain of the same animals and established the dependence of the blood cholesterol levels in his animals on the reactive processes of the ectodermal neuroglia cells of the brain. In the light of the view advanced by the author, the role of neuroglia in cholesterol

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