Nutritional studies in the domain of the vitamins have long since shown the fallacy of designating any one of these factors as peculiarly growth promoting; as a matter of fact, growth cannot ensue with all of these factors present in a diet which is inadequate for proper nutrition. Just as normal growth is dependent on a multiplicity of these extrinsic factors, so also the same may be said as to intrinsic factors, for more than one of the glands of internal secretion can be shown to have very definite relations with growth. When the thyroid, for example, is removed from a young mammal, growth is always impaired; growth ceases abruptly after hypophysectomy. In the last-mentioned instance, the claim that the cessation of growth has resulted from the removal of a pituitary hormone essential for growth has only gradually gained validation.As regards the nutritive, or extrinsic, factors influencing growth,
EVANS HM. GROWTH HORMONE OF THE ANTERIOR LOBE OF THE PITUITARY GLAND. JAMA. 1941;117(4):287–291. doi:10.1001/jama.1941.72820300035008
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