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September 10, 1927


JAMA. 1927;89(11):900. doi:10.1001/jama.1927.02690110064033

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To the Editor:  —In The Journal, July 30, appeared a communication from Dr. Edward J. Stieglitz in which he expressed the opinion that the editorial in The Journal, July 2, commenting on intracellular hydrogen ion concentration of living cells (Chambers, R., and Pollack, H.: J. Gen. Physiol.10:739, 1927) is misleading. Dr. Stieglitz cites his own work and that of Harvey and Bensley to show that considerable fluctuation in hydrogen ion concentration may be possible.This problem has been under intensive study in Dr. Chambers' laboratory, and we find that where such changes have been reported we are dealing with one of at least two conditions:

  1. The cell when injured becomes acid, and when killed loses its independence from the environment of maintaining its own hydrogen ion concentration.

  2. The dye may accumulate in intracellular granules and vacuoles which are secretory and excretory products of protoplasm, and register a color

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