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To the Editor:
—I have recently been asked for my opinion as a pharmacologist and toxicologist concerning an order made by a physician which was of such a nature that it is deemed desirable to publish a comment concerning it in this place. This order called for from twenty-five to thirty doses of nicotine alkaloid in solution, each dose containing one-thirtieth grain (2 mg.) of the nicotine alkaloid to be used by the physician for intramuscular injection in a patient.In my experience of twenty years as a physician and pharmacologist this was the first time that I have actually come across a prescription calling for nicotine to be used therapeutically (?), and as a specialist in pharmacology and experimental therapeutics I thought it worth while to review briefly the toxicology of nicotine for the benefit of the general profession.Nicotine is no longer recommended for therapeutic use in man. To
Macht DI. TOXICOLOGIC NOTE ON NICOTINE. JAMA. 1927;89(11):900. doi:10.1001/jama.1927.02690110064034
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