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September 10, 1927


Author Affiliations

Baltimore. Pharmacological Research Laboratory, Hynson, Westcott & Dunning.

JAMA. 1927;89(11):900. doi:10.1001/jama.1927.02690110064034

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To the Editor:  —I have recently been asked for my opinion as a pharmacologist and toxicologist concerning an order made by a physician which was of such a nature that it is deemed desirable to publish a comment concerning it in this place. This order called for from twenty-five to thirty doses of nicotine alkaloid in solution, each dose containing one-thirtieth grain (2 mg.) of the nicotine alkaloid to be used by the physician for intramuscular injection in a patient.In my experience of twenty years as a physician and pharmacologist this was the first time that I have actually come across a prescription calling for nicotine to be used therapeutically (?), and as a specialist in pharmacology and experimental therapeutics I thought it worth while to review briefly the toxicology of nicotine for the benefit of the general profession.Nicotine is no longer recommended for therapeutic use in man. To

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