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September 10, 1927

Ulcusproblem und Säurebasengleichgewicht. Eine klinischexperimentelle Studie.

JAMA. 1927;89(11):904. doi:10.1001/jama.1927.02690110068039

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This volume, the combined work of many investigators at the clinic of Dr. Balint at Budapest, advances a new theory as to the cause and treatment of peptic ulcers.

In the first chapter Dr. Balint broaches three questions as to the production of peptic ulcers, the first, What produces the original defect of substance comprising the ulcer? He does not believe it can be ascribed to any one factor. The rôle of antipepsin is undecided. However, he does ascribe tremendous influence to nervous factors. Stimulation of the parasympathetic (vagus) with toxins or the galvanic current produces either a vessel spasm in the gastric wall or a gastric contracture with secondary compression of the vessels. He doubts the infectious origin asserted by Rosenow. The second question is, Why does an ulcer become chronic? He does not credit this to nervous influences. However, the physiologic structure and activity of the stomach and

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