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Treatment of the late forms of parenchymatous syphilis of the nervous system has so far proved disappointing, even though it has seemed possible to secure remissions and possibly even arrest of the disease. Consequently, the main hope still lies in prevention. In this book Sézary reviews the frequency, etiology and time of invasion of the nervous system, his conclusions being founded largely on the results of his own observations. He asserts that a meningeal inflammation occurs in from one half to two thirds of all cases of syphilitic infection, though he also concludes that the invasion of the parenchyma is primary and not secondary to a meningitis and that it takes place during the septicemic phase of the disease. This should be sufficient to indicate the importance of examining the spinal fluid and studying every patient for signs of nervous involvement; the most opportune time for making the spinal puncture
La syphilis nerveuse: Etiologie.—Pathogénie.—Prophylaxie.—Traitement. Études cliniques et biologiques. JAMA. 1927;89(11):905. doi:10.1001/jama.1927.02690110069042
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