At the Meran meeting of the German Pathological Society in 1905, F. von Muller1 suggested the term nephrosis to distinguish the degenerative from the inflammatory lesions in the kidney. The clinical manifestations of the pathologic lesions which this term was to connote were not well known at this time. The term was objected to by Orth on the ground that it was too much like hydronephrosis, and by Aschoff on the ground of his views with respect to parenchymatous inflammation.
In 1913, Munk2 worked out the clinical symptoms of degenerative lesions, laying stress on the presence of double refracting bodies in the urine in one rather characteristic clinical syndrome. Munk at this time purposely avoided the term nephrosis on account of the objections raised to it by the pathologists mentioned.
In 1914, the monograph of Volhard and Fahr3 appeared. The clinical aspect of chronic interstitial nephritis was
McELROY JB. NEPHROSES. JAMA. 1927;89(12):940–945. doi:10.1001/jama.1927.02690120016006
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