The discovery that sulfanilamide in low concentrations which are tolerated in the animal body inhibits the growth of certain pathogenic bacteria has led to the use of this drug in the treatment of a wide variety of conditions. It has also stimulated experimental studies of the effects of the drug on various pathogenic organisms and on the animal body. As sulfanilamide is moderately toxic and affects only certain bacteria, a large number of related compounds have been synthesized and are being studied. The most widely used are sulfanilamide, sulfapyridine and sulfathiazole. It is possible that sulfadiazine may be added to this list (Feinstone and others,1 Long2).
Since sulfapyridine is particularly effective against the pneumococcus and is not more active against pyogenic organisms than are the other two drugs mentioned, orthopedic surgeons are not particularly interested in it.
In this paper I shall consider especially the use of sulfanilamide
KEY JA. THE USE OF SULFANILAMIDE AND SULFATHIAZOLE IN ORTHOPEDIC SURGERY: CHAIRMAN'S ADDRESS. JAMA. 1941;117(6):409–412. doi:10.1001/jama.1941.02820320001001
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