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September 17, 1927

Das Hormon der Herzbewegung.

JAMA. 1927;89(12):990. doi:10.1001/jama.1927.02690120066041

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In this booklet the author gives a summary of his experimental work on the so-called heart hormone, and a discussion of the results observed and their significance. This work was carried out on the frog at about the same time and independently of that of Demoor on the dog. In the basic experiment it was shown that the ventricle of a frog's heart, beating in normal Ringer's solution, was accelerated when this solution was replaced by one in which the sinus venosus had been beating. In short, that the Ringer's solution in which the sinus venosus had been beating contained what was probably some metabolic product of the activity of the beating portion of the sinus venosus that was capable of accelerating the ventricle. It was found, further, that the same product was capable of strengthening the pulse or of initiating contractions. In the same way material from the base

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