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To the Editor:
—Your editorial on the Graves syndrome in the issue of Dec. 27, 1930, and its criticism by Percy Fridenberg, January 31, page 376, merit further comment. Fridenberg asserts that the psychic factor "is certainly not of prime importance and probably not essential to the development of the disease. The emotional symptoms are possibly a result, not a cause, of the disease."The average clinician must heartily agree with the implications in your editorial and with the views of Eli Moschcowitz (The Nature of Graves' Disease, Arch. Int. Med. 46:610 [Oct.] 1930), A. S. Warthin (The Constitutional Entity of Exophthalmic Goiter and So-Called Toxic Adenoma, Ann. Int. Med. 2:553 [Dec.] 1928) and others in the opinion that exophthalmic goiter, whatever its ultimate cause, is a constitutional disorder in which the psyche is of major etiologic importance. Life is too limited to comprehend the ultimate cause of
Bram I. THE GRAVES SYNDROME. JAMA. 1931;96(9):710–711. doi:10.1001/jama.1931.02720350062030
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