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August 16, 1941


JAMA. 1941;117(7):527-533. doi:10.1001/jama.1941.72820330014007a

NORMAL AND PATHOLOGIC PHYSIOLOGY OF PARATHYROID GLANDS  The parathyroid hormone has a marked influence on the metabolism of calcium and phosphorus. Its primary action, in my opinion, for reasons which cannot be gone into, is on phosphorus metabolism, and the changes in the metabolism of calcium are dependent on the preceding changes in the metabolism of phosphorus.1

Calcium Metabolism.—  The metabolism of calcium is considerably simpler than that of phosphorus. Over 99 per cent of the body's calcium is in the form of a calcium phosphatecalcium carbonate compound which is deposited in the organic matrix of bone and teeth. In addition, there are small amounts of calcium in body fluids. The calcium in the blood except for a negligible part is in two forms, calcium ions and calcium proteinate.2 The parathyroid hormone apparently regulates the level of calcium ions. There is considerable circumstantial evidence that the stimulus