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August 23, 1941


JAMA. 1941;117(8):595-600. doi:10.1001/jama.1941.02820340017006

The cause of Hodgkin's disease remains obscure, but the theories of the causative factors are well known. The possible significance of the recent reports of Wise and Poston,1 who have demonstrated the frequent presence of Brucella melitensis in the lymph nodes of patients with lymphogranulomatosis, is yet to be established. These workers have analyzed their results with commendable objectivity and without ascribing a final etiologic relationship to these organisms. Dr. E. A. Birge2 has cultured specimens from the lymph nodes of 10 patients with Hodgkin's disease seen at the Wisconsin General Hospital but has been unable to demonstrate Brucella organisms. It should be observed, however, that brucellosis is much less common in Wisconsin than in the regions where the patients of Wise and Poston1 live. This factor has already been weighed by these observers, and further discussion of it is unnecessary.

The therapy of Hodgkin's disease is