It is now well established that certain products derived from activated ergosterol are highly effective in increasing the concentration of calcium in the blood and in relieving the symptoms of parathyroid insufficiency. It appears, from some years of accumulated clinical experience, that these products may be administered over a considerable time with reasonable safety, provided proper precautions are observed, and that their prolonged use is attended neither by injury to the patient nor by the development of tolerance.
The subject of the management of hypoparathyroidism with the activated sterols assumes especial importance because of the fact that substitution therapy, in the form of administration of solution of parathyroid, is virtually limited to rather acute conditions, in which the treatment needs to be continued for days or weeks rather than months.1 Not only is no tolerance to the activated sterols developed but they also have the decided advantage that the
McLEAN FC. ACTIVATED STEROLS IN THE TREATMENT OF PARATHYROID INSUFFICIENCY: A REVIEW. JAMA. 1941;117(8):609–619. doi:10.1001/jama.1941.72820340003009
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