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August 23, 1941

Current Comment

JAMA. 1941;117(8):622. doi:10.1001/jama.1941.02820340044013

ESSENTIAL FRUCTOSURIA  Essential fructosuria is a rare anomaly of metabolism, apparently harmless but sometimes mistaken for diabetes. It is characterized by inability to utilize fructose completely. The disturbance is manifested by the presence of fructose in the urine in amounts proportional to the quantity of sugar ingested. Because of its rarity it has been difficult to speculate convincingly concerning the etiology. Now however Lasker,1 by adding 7 new cases to the literature and analyzing them as well as the 40 previously reported, is enabled to demonstrate a familial occurrence. Although the evidence for inheritance of this disturbance is not yet conclusive, its occurrence in sibs, its nonoccurrence in the parents and offspring of persons with fructosuria, and the frequency of consanguininity of parents of such persons all offer evidence to indicate that fructosuria is inherited as a mendelian recessive characteristic. Final confirmation of this theory may be long in