Preliminary reports of the treatment of compound fractures with sulfonamides with or without metallic internal fixation, and as a rule with primary closure of the wound, were couched in rather conservative terms. After three years of experience with this method, certain favorable impressions deduced in the beginning can now be changed to fairly definite conclusions. The series subsequently to be reported is a representative cross section consisting of 50 private patients treated under optimum surgical conditions with adequate post-operative care and follow-up and 93 municipal hospital patients treated under less favorable conditions. The adoption of this method of treatment is sufficient indication that other routines previously utilized had not been entirely satisfactory.
In addition to the administration of sulfonamides and primary closure of the wound, metallic internal fixation has been utilized in 42 cases. While primary fixation in compound fractures has been used previously and satisfactory results have been reported
CAMPBELL WC, SMITH H. FRESH COMPOUND FRACTURES: TREATMENT BY SULFONAMIDES AND BY INTERNAL FIXATION IN SELECTED CASES. JAMA. 1941;117(9):672–675. doi:10.1001/jama.1941.02820350012004
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