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Article
March 7, 1931

HERPES ZOSTER WITH VARICELLA: A CLINICOPATHOLOGIC STUDY

Author Affiliations

ENDICOTT, N. Y.

JAMA. 1931;96(10):766-770. doi:10.1001/jama.1931.02720360036008
Abstract

The subject of interrelationship of diseases is wide in extent and clinical observation is vast in its scope. Progress in the study of this interrelationship is being maintained by the observation of immunities created by certain acute diseases to other diseases, equally acute or chronic.

The occurrence of four cases of herpes zoster simultaneously, among apparently healthy young adults in contact in the same occupation, evoked some interest. Further interest was created in that one of these patients, on the twelfth day following the appearance of the herpes zoster, developed a generalized varicellalike eruption. As the cases occurred in midwinter in the midst of a rather severe epidemic of varicella, a clinical relationship between the two diseases was apparent.

Literature dealing with the association of herpes zoster and varicella is becoming increasingly voluminous both in the quantity of clinical cases observed and in the experimental work being performed. In 1888

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