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This, the first French monograph on creatine, is a thorough review and evaluation of the literature, particularly from the pathologic and clinical points of view. A brief historical introduction is followed by a discussion of the chemical and physical properties, the structural relations between creatine and creatinine and a list of their derivatives without any data on their properties. The usual possible precursors and degradation products are also given. The analytic section is presented in a fairly critical manner. Although the specific enzyme method of Miller and Dubos is referred to, a detailed description is not given. The authors' own observations are based on results with their own method, which is an improvement over the Folin procedure but which lacks the specificity of the enzyme method. The method for estimating phosphagen phosphate is accepted without questioning either its specificity or the interpretations based thereon. Unfortunately the authors have not, in
La créatine: Étude physio-pathologique. JAMA. 1941;117(9):815. doi:10.1001/jama.1941.02820350155030
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