Removal of a dog's pancreas produces in that animal a series of metabolic changes which are strikingly similar to those of severe diabetes mellitus in human subjects. No less definite is the speedy elimination of these abnormalities in both the depancreatized dog and the patient with diabetes following the injection of insulin, which is obtained from normal pancreatic tissue. The observations on the effects of pancreatectomy, made by von Mering and Minkowski,1 and those on the effect of insulin on depancreatized dogs, made by the group in the department of physiology of the University of Toronto,2 provided very good evidence for the association of the pancreas and its internal secretion with the condition of diabetes. These salient facts have been added to extensively during the last few years. Some of the additions have established older views more definitely, whereas some have led to entirely new conceptions of the
WATERS ET, BEST CH. THE PANCREAS AS AN ORGAN OF INTERNAL SECRETION. JAMA. 1941;117(10):852–859. doi:10.1001/jama.1941.72820360003011
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