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Article
October 8, 1927

MEDICAL TREATMENT IN DISEASES OF THE LIVER AND BILE PASSAGES

Author Affiliations

ROCHESTER, MINN.
From the Division of Medicine, Mayo Clinic.

JAMA. 1927;89(15):1209-1215. doi:10.1001/jama.1927.02690150019006
Abstract

The recent accumulation of information with regard to the physiology of the liver has served to provide the medical profession with new clinical and laboratory criteria of hepatic disorders. The therapeutics of hepatic disease has lagged somewhat behind the general advance of knowledge in this field, although a number of notable contributions have been made to both medical and surgical management.

GENERAL PREVENTIVE MEASURES  The liver, like the kidney, is susceptible to injury from infections and toxic substances; among the latter may be mentioned a group of chemicals, such as phosphorus, chloroform, phenylhydrazine, trinitrotoluene, tetrachlorethane, trinitrophenol and carbon tetrachloride, all of which have been shown to produce hepatic lesions in the experimental animal or in man.Alcohol has always loomed large as an etiologic agent in portal cirrhosis and, while no conclusive experimental proof of its relation to hepatic disease has ever been offered, clinical experience has established its importance

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