Nine years ago Minot1 said "Pernicious anemia like other deficient states should be treated on a quantitative basis—treatment should fill the body adequately with stores or a reserve supply of the substance." Treatment by injections of a bovine liver extract stores a deficient organ, the human liver, with a specific hemopoietic substance, which is apparently identical in normal bovine and human livers. This substance is stored in such livers and has certain specific characteristics: it is both heat stable and parenterally effective. These composite properties distinguish it from the anti-pernicious anemia material in other organs which is not effective when given by injection.2 The liver of a patient who has pernicious anemia and is in relapse contains no detectable amount of this material, but after treatment with the bovine extract it yields a similar heat stable, parenterally effective substance. Since the liver is the only bovine organ that
ASKEY JM. QUANTITATIVE TREATMENT OF PERNICIOUS ANEMIARESPONSE TO INITIAL MASSIVE DOSE OF LIVER EXTRACT IN RELAPSE. JAMA. 1941;117(11):907–910. doi:10.1001/jama.1941.02820370003002
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