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September 13, 1941

QUANTITATIVE TREATMENT OF PERNICIOUS ANEMIARESPONSE TO INITIAL MASSIVE DOSE OF LIVER EXTRACT IN RELAPSE

JAMA. 1941;117(11):907-910. doi:10.1001/jama.1941.02820370003002
Abstract

Nine years ago Minot1 said "Pernicious anemia like other deficient states should be treated on a quantitative basis—treatment should fill the body adequately with stores or a reserve supply of the substance." Treatment by injections of a bovine liver extract stores a deficient organ, the human liver, with a specific hemopoietic substance, which is apparently identical in normal bovine and human livers. This substance is stored in such livers and has certain specific characteristics: it is both heat stable and parenterally effective. These composite properties distinguish it from the anti-pernicious anemia material in other organs which is not effective when given by injection.2 The liver of a patient who has pernicious anemia and is in relapse contains no detectable amount of this material, but after treatment with the bovine extract it yields a similar heat stable, parenterally effective substance. Since the liver is the only bovine organ that

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