Progress in the recognition of vitamin B deficiency states in human beings has been hampered by the lack of simple and reliable laboratory tests. As a result, clinicians have resorted to the therapeutic trial as their main aid in the diagnosis of these deficiencies. Many worthwhile advances have been made in this way, but, because of uncontrolled variables, many errors have also been made. The "Give-a-dose, if-the-patient-feels-better-he-has-a-deficiency" school of research workers has aroused a storm of criticism, causing conservative clinicians to be extremely skeptical of their reported results. To the discerning and critical clinician it has become apparent that, in the absence of specific tests for deficiency of the various components of the vitamin B complex, reliance must be placed on other types of objective criteria and not merely on the patient's increased sense of well being. It is with this point in mind that we present this report based
LEPORE MJ, GOLDEN R. A SYNDROME DUE TO DEFICIENCY OF THE VITAMIN B COMPLEX. JAMA. 1941;117(11):918–923. doi:10.1001/jama.1941.02820370014005
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